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A barren couple is now pregnant with a "baby of three parents"



After four cycles of in vitro fertilization, a Greek woman and her partner have not yet been able to conceive. But now the 32-year-old woman is pregnant – and her baby will be born with DNA from three people.

While other pairs have used the same procedure known as replacement mitochondrial therapy to prevent their progeny from inheriting genetic diseases. this is the first time the researchers use it in a clinical trial to treat infertility – a signaling of new hope for millions of couples around the world who have conception problems.

to mitochondrial replacement therapy, doctors place the kernel of a female egg in a donor egg whose core has been removed. They then fertilize the egg with sperm and implant them into the woman.

This allows the couple to avoid inheriting the baby from health problems associated with female mitochondria that exist in the egg but outside the kernel. the kernel contains 99.8% of a person's genes, the baby will inherit most of his mother's DNA together with his father ̵

1; but there will also be some DNA from the donor, hence the term "baby of three parents."

A Jordanian gave birth to the first baby conceived via mitochondrial replacement therapy. However, she has been subjected to a procedure to prevent the inheritance of Lee's syndrome, a genetic defect that would be fatal to the baby.

Next year, doctors in Ukraine say they have helped a barren couple conceive through the same therapy. However, this pregnancy was not part of an official clinical trial, unlike what was undertaken by a team of Spanish Embryotools and the Greek Institute of Life. New pregnancy of a Greek woman may be a sign that replacement mitochondrial therapy is a viable option for infertile couples – but we still have a long way to travel before becoming a general infertility treatment, according to Embryotools Director Gloria Calderon.


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