During a Scottish woman she broke her bones, burned her skin and was subjected to surgery without feeling pain – and she did not realize it was she was experiencing something unusual while she was in her 60s, according to a new study
Scientists are interested in people who feel less ill because they hope to find ways to help those who suffer from it. In this case, the woman has visited the hospital for a "usually painful" hand operation, but then it does not require any painkillers. Thinking this seems odd, a team of researchers has been able to determine her condition as a pair of genetic mutations.
The woman was previously diagnosed with thigh arthritis, which she did not feel despite the "severe" grade. of joint degeneration, "according to the report. She lived a long life of painlessness before she realized something strange, reporting dental offices without anesthesia, painless cuts and broken bones, and even burns that smelled her charred flesh to notice something wrong. He even told the researchers that he could eat chili peppers with a pendant without any effects other than a "nice shine" in her mouth. Oh, and she rarely felt any worry, depression, fear or panic – even during the doctors' told her to talk to the pain genetics team at London University College, which ranks parts of her, the genomes of her children and her mother, and asked them about their tolerance for pain. The culprit seems to be a small set of missing DNA in FAAH-OUT's pseudogene, essentially degraded versions of fully functional genes that were once considered "junk" but often play a role. The woman also had a single switching nucleotide (DNA construct) in her FAAH gene, which was responsible for an enzyme called fatty acid amide hydrolase. Previous studies also show that people with small variations in their FAAH gene have less anxiety and feel less pain.
Now, researchers are hoping to explore this part of our genome to help those suffering from chronic pain and anxiety, according to an article published in the British Journal of Anesthesia.
"It is really exciting to work with rare pain-insensitive patients and hopefully identify new analgesic drug targets as a consequence of this work," study author James Cox of the Institute of Biomedical Research at University College London said: of Gizmodo
The article states that previous drug trials attempting to stop the pain by inhibiting the production of FAAH are not fruitful. But, perhaps, it is directed to the FAAH-OUT pseudogene, instead, it may be a better strategy.
This is ultimately just one study and there is a lot more work to be able to declare the victory over the pain. Nor is this the only part of the genome related to pain. Other genes also seem to have an impact on how people feel pain, as in the case of Italian Professor Letizia Marsili. Marsili does not feel pain due to a mutation in her ZFHX2 gene.
Pain has an important purpose, of course – it would suck to find out that you were blazing because of the smell of your own burning flesh. But pain, especially chronic pain, can significantly reduce the quality of life of the person, and new pain reduction strategies are needed. Coke hopes scientists will be able to develop new therapies to treat this age-old disease with the help of gene-editing technology.