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Anorexia is not just a psychiatric problem, scientists say



Scientists have found that anorexia nervously is not a purely psychiatric condition but is provoked by metabolic problems.

Finding can help explain the poor results of doctors in treating the disease and pave the way. for radical new approaches to predict and treat those most at risk

Researchers have made the finding by comparing DNA of nearly 17,000 anorexic patients and more than 55,000 healthy controls. Those with anorexia submitted their DNA through the Nervous Anorexics Genetics Initiative or the Working Group on Nutritional Disorders in the Consortium for Psychiatric Genomics. But it is also found that DNA is involved in fat burning, is physically active and has type 2 diabetes resistance. "What the study suggests to us that we can no longer cure anorexia, perhaps other dietary disorders as purely psychiatric or psychological. "Says Gerom Brin, a geneticist at King's College London, who runs the study with American scientists at the University of North Carolina at Chapel Hill. "Anorexia has the expected correlations with anxiety, depression and OCD, but it also has this set of apparently healthy metabolic correlations that we do not see in other mental disorders," Brin adds. Although they look healthy, the metabolism genes seem to be matched with genes related to psychiatric problems to increase the risk of anorexia. About half of the anorexia is explained by genetics, the rest is due to life events and other factors.

Anorexia nervosa is the most deadly of all mental illnesses. It affects between 1

% and 4% of women and about 0.3% of men. Those affected may have a dangerously low body weight and a distorted picture of what their body looks like and can be terrified by the load. While some eat so little that they are actually starving, others eat normally but exercise to the extent that they burn more calories than they consume. The disorder can be treated with a combination of psychological interventions such as cognitive-behavioral therapy (CBT). and family eating programs that aim to bring people back to their healthy weight with the support of their family. But they are not always successful.

Doctors have long believed that the family environment is a factor for anorexia nervosa, but in some cases even widespread convictions may go wrong. Perfectionism, for example, is blamed as a cause of anorexia, but the last job suggests it is the opposite. "Families of people with anorexia usually have higher levels of perfectionism in them, but we think people get the wrong causes and consequences. This is not the perfectionism that causes anorexia and the tendency to have anorexia that causes increased perfectionism, "Brin said. "What we think is happening is that the family environment and genetics interact." The eight genes identified in the study account for only a small portion of the anorexia. As with many medical conditions, there are probably hundreds or thousands of genes that contribute to the risk of developing the disease.

Brin said that now scientists need to study the metabolism of people with anorexia and other eating disorders to see if it is possible to develop metabolism-based therapies or to notice people at risk of recurrence, common problem in anorexia. , "Anticipating recidivism is one of the most valuable things we can do," he said. The study is published in Nature Genetics.

Rebecca Park, a consultant psychiatrist who studies nutritional disorders at Oxford University, says that although work does not provide immediate solutions, this may lead to new ways of treating anorexia. 19659002] "This job adds something really important," she said. "This gives a message to the sufferers and their families and professionals who offer or develop treatment that anorexia can not be conceptualized as the only psychiatric condition. Rather, metabolic factors can also contribute to this.

"I hope that over time these findings will lead to new treatment approaches and will begin to change the culture of guilt that sufferers should simply be able to get out of it."

She said: "We know we need more effective treatments for anorexia nervosa. He is very much based on attempts to stop starvation in his traces, but often this process does not work. The most important message comes in early, at first. "


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