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Antiviral nasal spray can fight coronavirus, studies have found



A nasal spray that can protect against coronavirus was formulated by researchers at the University of California, San Francisco, according to a report. Researchers are now working to test and manufacture it clinically.

The aerosol spray, called AeroNabs, is an antiviral aimed at preventing COVID-19, although it is not a cure, the researchers said in a statement. They added that it could be a good weapon against a new coronavirus until a vaccine is found or a potential alternative for those who do not respond to the vaccine.

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“Far more effective than wearable forms of personal protective equipment, we think of AeroNabs as a molecular form of PPE that can serve as an important stop until vaccines provide a more durable solution for COVID-19,” says Peter Walter. -р. , a professor of biochemistry and biophysics at UCSF and an investigator at the Howard Hughes Medical Institute, in a press release.

“For those who cannot access or respond to SARS-CoV-2 vaccines, AeroNabs can be a more permanent line of defense against COVID-19,” added Walter, who is also the inventor of AeroNabs.

The scientists said in the publication that they were inspired by nanobodies that are like antibodies found in llamas and camels.

“Although they function very similarly to antibodies found in the human immune system, nanobodies offer a number of unique benefits for effective therapeutic agents against SARS-CoV-2,” said co-inventor Ashish Manglik, MD, associate professor of pharmaceutical chemistry. in a statement.

Coronavirus (COVID-19. (3D rendering)

Coronavirus (COVID-19. (3D rendering)
(redit: BlackJack3D / iStock)

The researchers explained that SARS-CoV-2 relies on rosehip proteins to infect human cells.

“They are the main key that allows the virus to enter our cells,” they said.

The researchers explained that when the coronavirus particle is activated, spike receptors are primed to attach to ACE2 (angiotensin-converting enzyme 2) inhibitors, which are found in human cells that line the nasal passage, lungs and airways. Recently, researchers in the field of coronavirus told Fox News that this is the point of entry of the virus.

The authors explain in the report that they have developed single-domain antibodies (nanobodies) that severely disrupt the interaction between SARS-CoV-2 Spike and ACE2. binds to the spikes and blocks the interaction of ACE2, thus blocking the virus from invading the host.

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The researchers explained in the news release that the most powerful nanobodies act not only as a shell surrounding spike receptors, but also as a “molecular mouse that clings to a spike in its closed, inactive state, which adds an extra layer of protection against spike-to-interaction.” ACE2, which leads to infection. “

The nanobodies remained a powerful antiviral SARS-CoV-2 when tested in aerosolized form, according to the news release. This means that it would be practical to administer it using a stable inhaler or nasal spray. This aerosol form could provide “an easy prophylactic and / or early infectious therapeutic agent for the patient to end the worst pandemic of a century,” the researchers said.


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