- Until recently, the CRISPR gene editing tool was able to make changes only within single genes.
- New tools allow scientists to cut and weave larger pieces of genetic material.
- The results are likely to have significant impact implications for different research areas, and also allow researchers to create synthetic species that can produce molecules that are not made from natural organisms.
Since 2012, the CRISPR / Cas9 gene editing tool has enabled scientists to target and modify DNA with remarkable precision. But one of the limitations of this technique is that it is able to make changes only within single genes. Now, scientists have developed new tools that allow them to cut and weave large chromosome pieces and assemble new synthetic genomes from different strains.
The results, published in an article on August 30th in Science are likely to have serious implications for areas such as synthetic biology, computational biology and biological calculations and could lead to better treatment of a wide range of diseases .
"This new book is an incredibly exciting and huge step forward for synthetic biology," Ann Mayer, a synthetic biologist at the University of Rochester in New York who did not participate in the paper, told Science Science [1
Researchers, as reported by RF Service for Science Science also modify "another well-known agent, an enzyme called lambda-red recombination, so that it can glue the ends of the original chromosome – minus the removed part – again together, as well as blind ends of the removed part. Both circular strands of DNA are protected by endonucleases. The technique can create different circular chromosome pairs in other cells and researchers can then swap chromosomes as desired, ultimately account to insert what "
" Now, I can make sir changes in one segment and then combine them in another. That's a big deal, "says Chang Liu, a synthetic biologist at the University of California, Irvine. , Science .
Why CRISPR Gene Editing Gives Nightmares to Its Creators
New tools are likely to open the door for scientists to explore many new fields: creating synthetic species that can produce molecules that are not produced by natural organisms, it stores information in DNA for use as a storage device and reduces the cost of medical research, making it easier to edit bacterial genomes on a larger scale.
However, the use of CRISPR to edit large sections of the human genome is unlikely to occur any time soon, given regulatory obstacles and ethical complications. In the end, scientists are not fully aware of the implications of making small DNA edits, much smaller cuts.
"We don't always fully understand the changes we make," says Alan Regenberg, a bioethicist at the Johns Hopkins Berman Institute of Bioethics before Science News . "Even if we make the changes we want to make, there is still a question of whether he will do what we want and not do the things we don't want."
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