The award is considered to be the highest acclaim in comedy and recognizes individuals who have influenced American society in the veins of 19th-century novelist and essayist Samuel Clemens or alias Mark Twain.
"I love my art form, because I understand every practitioner in it, whether I agree with them or not know where they come from. They want to be heard, they have something to say, there is something they notice. They just want to be understood. "I love this genre, it saved my life."
A number of entertaining artists, including Chapel's writing partner Neal Brennan, General, Bradley Cooper, Tiffany Hadish, John Legend, Chrissy Teigen, Lorne Michaels, Trevor Noah , John Stuart, and others, paid tribute to the comedian.
Stewart went on to say that Chapel is "a man who seeks people and experience and knowledge, and wants to touch him and to feel him and be with him on earth so that he can then channel him through his art and then direct him back to something completely different and new. " Stuart also attended the Chapel benefit concert after the mass shooting in Dayton, Ohio.
Actor and comedian Eddie Murphy said in a video tribute to Chapelle is the type of person who is "so much smarter than everyone".
"Dave is one of probably the most intellectual comedian ever," Murphy said.
Past recipients of the Mark Twain Award include Richard Pryor, Jonathan Winters, Carl Rainer, Uppy Goldberg, Lily Tomlin, Lorn Michaels, Steve Martin, George Carlin, Tina Fey, Will Ferrell, Ellen Degeneres, Carol Burnett, Carol Burnett Letterman and Julia Louis-Dreyfus.