Scientists say they have discovered the secret that some people are weak while others are easily accumulating. Their work reveals the newly discovered genetic regions associated with being very weak.
The international team says this supports the idea that for some people thinness has more to do with inheriting a "lucky" set of genes than with a perfect diet or lifestyle. The study appears in PLOS Genetics. Over the last few decades, researchers have discovered hundreds of genetic changes that increase the chance of being overweight ̵
1; but there is much less focus on the genes of people who are thin.
In this study, scientists compared DNA samples from 1,600 healthy thin people in the UK – with a body mass index (BMI) of less than 18 – with those of 2000 heavily obese people and 10,400 of normal weight.
They also looked closely at lifestyle questionnaires – to exclude, for example, eating disorders. Researchers have found that overweight people are more likely to have a set of overweight related genes. Meanwhile, people who were weak did not only have fewer obesity-related genes, but they also had changes in the gene regions that were associated with healthy finesse.
Leading researcher Prof. Saddam Faruki of the University of Cambridge has called on people to be less condemned for the weight of others. This study shows for the first time that healthy thin people are usually thin because they have a lower weight than genes that increase the chances of a person being overweight rather than because they are morally superior as some people they love to offer, "
" It's easy to rush to judge and criticize people for their weight, but science shows that things are far more complicated
"We have much less control over our weight than we would wanted to think. "
Scientists say the next step is to determine the right genes involved in healthy sophistication
Their longer term goal is to see if this new knowledge can help shape new weight loss strategies. 19659014] Professor Tom Sanders, a professor of nutrition and dietetics at King's College London, commented on the study, "This is an important and well conducted study confirming that premature heavy obesity is often genetically defined and shows unconscious, that those who are very thin are genet different from the general population. "
But he added:" Most obesity is acquired in adulthood and is associated with the obesogenic environment in which we live – a sedentary lifestyle and rich access to calories
Tim Spectrum, also from London's Royal College, said that about a third of people in most countries managed to remain weak anyway. "Some of them are due to genes, but other factors such as an individual Differences in lifestyle or intestines of microbes are likely to be also responsible," he said.
Health experts say that whatever form or your genetic composition, the age-old counsel for a healthy level of physical activity, and a good diet are still standing