Just in time for Halloween, doctors in France claim to have witnessed a real-life horror story involving an antibubicide resistant superstorm. In less than a month, their patient's infection develops drug resistance in the last resort they used to treat it. Fortunately, the doctors still managed to overcome the microscopic threat – and the case may have revealed a particular weakness in the embryo.
According to a report from published in the journal Antimicrobial Agents and Chemotherapy, a young child has been dealing with recurrent bacterial infections Pseudomonas aeruginosa P. aeruginosa is an opportunistic infection that afflicts tens of thousands of already weakened people in hospitals and other health care facilities in the United States . In these people, it can cause serious infections .
This was the case with this patient whose rare liver disease required him to receive two liver transplants, the first at age three. After the second operation, the patient developed several life-threatening infections, including one caused by P. aeruginosa in March 201
Initially, the glitch appeared to be completely vulnerable to the latter – resort drug ceftolactosan terazo-tazoban terazo-taziban-tazoban. of two powerful antibiotics. But 22 days after treatment, doctors found a bacterial strain in their patient who had developed drug resistance. Other scientists have found that P. aeruginosa can develop resistance to ceftolosan-tazobactam in the laboratory, but according to the authors, it is rarely documented in real patients (in life, much less for such a short name ).
treatment was still sufficient to defeat the original infection, as well as two other infections caused by P. aeruginosa in the next two and a half. year. But the case gave doctors a chance to study closely how it was developing. So they sequenced and compared the genomes of dozens of samples collected from their patient.
During this period, they found that the superbug had developed resistance to at least resort medicine ] three times. These events seem to occur independently from each other instead of surviving and returning with a vengeance. But they all happened in the same way, caused by a single mutation in the bacterium.
Interestingly, while the mutation made bacteria better at fighting the latter, a resort remedy, it also seems to be restoring its weakness to some of the drugs it has previously resisted. This could mean that the authors write that even terrible cases such as this can be treated through "potential alternative therapy" that relies on older drugs. The finding may even help doctors in the future find a way to prevent this kind of resistance from occurring in the first place, they added.
However, as many horrors are – a movie monster that won't stay dead, superbugs come up with all sorts of tricks that allow them to escape death. And it is more than possible, if not inevitable, that a strain of P. aeruginosa or another bacterium may one day combine the right combination of mutations that allow it to resist the last resort and maintain its existing vulnerabilities. Just another fun opportunity to think late into the night!