At that time, Juul, the best-selling in the United States, was not available in the United Kingdom, Juul had much higher concentrations of nicotine – either 59 milligrams or 35 milligrams.
All participants had an individual width in within their study groups to bring real-life scenarios closer together. When the pads finished the bottle of nicotine fluid, they could choose whatever nicotine taste and power to buy. They were even encouraged to combine them; Most have done so, usually by choosing a patch and oral therapy.
Because smoking abstinence self-assessments are not considered reliable, researchers measure the amount of carbon monoxide in the breathing of participants, more accurately validating. Dr. Maciej Goniewicz, a co-author of the British study, who is now a pharmacologist at Roswell Park's Universal Cancer Center in Buffalo, New York, said the success of electronic cigarettes most likely reflects a combination of factors:
Dr. Benovic noted that higher interruptions and compliance among e-cigarette users could be further explained as these subjects expressed greater satisfaction with the devices than the other group with their products.
In his editorial, Drs. Borelli and O'Connor have cited other studies on smoking cessation therapies: In one study, nicotine replacement therapy and the antidepressant bupropion (Wellbutrin) achieved slightly higher levels of abstinence than e-cigarettes in this last trial. The prescribed drug varenicline (Chantix) is even moderately better. In addition, these products have proven safe, they say.