European markets opened lower on Wednesday led by France's CAC off by 0.5 percent.
Asian stocks were mixed Wednesday as uneasy investors watched for signs of progress on US-China trade after Wall Street slides.
Japan's Nikkei ended the day with a slight gain of 0.1 percent. China's Shanghai retreated by 0.3 percent and Hong Kong was off by 0.2 percent.
U.S. Equity futures were pointing to a slightly higher open, trimming some of the overnight gains.
Investors who worry the US-Chinese tariff war will drag the global economy into recession were left guessing after President Trump's conflicting comments on trade talks. [1
On Wall Street, investors shifted money from stocks to the U.S. government bonds, gold and other traditional safe-haven assets.
|I: DJI||DOW JONES AVERAGES||25777.9  -120.93||-0.47%|
|I: COMP||NASDAQ COMPOSITE INDEX ||-26.79||-0.34%|
In the Tuesday session, the S&P 500 index fell 0.3 percent, the Dow Jones Industrial Average dropped 0.5 percent and the Nasdaq slid 0.3 percent.
US and Chinese trade negotiators are due to meet next month in Washington, but neither side has any indication of offering concessions to break a deadlock. A round of talks last month in Shanghai ended with no sign of progress.
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Washington and Beijing fueled investor pessimism on Friday with an additional round of tit- for-tat tariff hikes. Their punitive duties on billions of dollars of each other's goods already have battered exporters on both sides and prompted forecasters to cut economic growth outlooks.
The Associated Press contributed to this article.