Francesco Cali, 53, was found with multiple torso wounds. A law enforcement official confirmed to CNN that the victim was a high-ranking member of the Gaminno family of crimes and is believed to be the incumbent boss.
The police responded to a 911 call Wednesday night for an assault on a home in New York City's Stathon neighborhood.
Police say there are no arrests and the investigation continues.
He is the first boss of a criminal family in New York for 34 years, according to the station. In 1985, Paul Castellano was executed when he arrived at Manhattan's Sparks Steakhouse restaurant. Gotti and his soldier Sammy "Bul" Gravano, allegedly, watched the action closely.