George Kittel, who is on the Niners' list as suspected of knee and ankle injuries, will miss his second straight game Sunday when the San Francisco visiting Cardinals in Arizona, said a source for Adam Schefter on ESPN.
The Niners will also run without running back Matt Brad and kicker Robbie Gould, a source told Schefter. Wide receiver Emmanuel Sanders, who was suspected of a rib injury suffered during the first quarter of Monday, will lose the Seattle Seahawks overtime, according to a source on Sunday.
Whale was wounded in the Week 9 win over the 49ers over the Cardinals. His absence leaves the team without the highest threat of receiving, as Kitle leads the Niners in receptions (46), receiving yards (541
With Kittle out, Ross Dwelley and Levine Toilolo's backups will be relied upon to fill the gap at a tight end.
Breida, who has a team-best 542 rushing yards this season, was declared doubtful Sunday for an ankle injury.
Gould was doubtful to play on Sunday because of a quarterback injury and would miss his second straight game. Chase McLaughlin, who was 3-for-4 in field goal attempts against the Seahawks, will again take Gould's place.
Sanders received some cartilage damage in his ribs during the first quarter of Monday, although he tried to play through it. These efforts ended early in the second quarter when he left for the locker room and did not return.
The Niners traded for Sanders on Oct. 22, hoping he could be the missing piece needed to push the team to Super Bowl Claimant status. Sanders wasted no time making an impact, posting 14 catches for 137 yards and two touchdowns in his first two games.