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In a basic meta-analysis, omega-3 fish oil supplements linked to cardiovascular wax



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People who received omega-3 fish oil supplements in randomized clinical trials had a lower risk of heart attack and other cardiovascular disease (CVD) than those receiving placebo, according to a new meta analysis by Harvard TH Chan School of Public Health and Brigham and Women's Hospital. The researchers found a link between daily supplementation of omega-3s and a reduced risk of most CVD outcomes, including heart attack, coronary heart disease and CVD death, but did not see a stroke benefit. In addition, higher doses of omega-3 fish oils add to an even greater risk reduction.

The study will be published online on September 30, 201

9 in the Journal of the American Heart Association .

"This meta-analysis provides the most up-to-date evidence for the effects of omega-3 supplements at the risk of multiple CVD outcomes. We have found significant protective effects of daily omega-3 supplementation against most of the risks of CVD leakage, and it appears that associations are dose dependent, "says first author Yan Hu Hu, PhD in

While surveillance studies have shown a link between fish consumption and lower risk of heart disease, the results of randomized controlled trials (RCTs) secutive. Two reviews published last year found no clear evidence of benefit.

In this new analysis, the researchers performed an updated meta-analysis that included three recently completed large-scale studies, which increased the sample size by 64%. The total population analyzed by Hu and colleagues includes more than 120,000 adults in 13 randomized trials worldwide. The analysis includes the VITAL trial, the largest randomized trial of omega-3s to date.

Discoveries show that people taking daily omega-3 fish oil supplements, compared to those taking placebo, reduced their risk for most CVD outcomes other than stroke, including an 8% reduced risk of heart attack and coronary death heart disease (CHD). The association was particularly evident with higher doses of omega-3 fish oil supplementation. This finding may suggest that a marine dose of omega-3 supplement over 840 mg / day used in most randomized clinical trials may provide a greater reduction in the risk of CVD. Given that several million people experience these CVDs worldwide each year, even a small reduction in the risk can turn into hundreds of thousands of heart attacks and avoidance of CVD death, according to researchers.

"Although public health recommendations should focus on increasing fish consumption, overall healthy diet, physical activity and other lifestyle practices, this study suggests that omega-3 supplements may play a role in appropriate patients, "said senior author JoAn Manson, chief of Brigham's Medicine Prevention Unit and Women's Hospital and a lecturer in the epidemiology department at Harvard Chan School. Manson is also director of the VITAL omega-3 large-scale study.


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More information:
Journal of the American Heart Association (2019). DOI: 10.1161 / JAHA.119.013543

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Harvard T.H. Chan School of Public Health

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In a major meta-analysis, omega-3 fish oil supplements linked to cardiovascular wax (2019, September 30)
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