The defense spokesman said Baghdadi appeared to have blown a suicide vest during the attack.
The CIA is helping to find the ISIS leader, the defense official said.
Newsweek first reports that Baghdadi is believed to have been killed
President Donald Trump is scheduled to make a keynote address Sunday at 9 a.m., White House Deputy Secretary Hogan Gidley announced. An administration official tells CNN that the message is related to foreign policy.
The Pentagon did not immediately respond to a request for comment.
Baghdadi, the leader of the terrorist group, has been hiding for the past five years. In April, a video from the ISIS media wing Al-Furqan was released, showing a man alleged to be Baghdad. Baghdadi was first seen in July 201
In February 2018, several US officials said Baghdadi was injured in an air strike in May 2017 and had to relinquish control of the terrorist group for up to five months because of his injuries.
Baghdadi became the leader of the Islamic State in Iraq (ISI) in 2010. In 2013, ISI announced the acceptance of an al-Qaeda-backed fighting group in Syria, and Baghdadi stated that its group would now be known as the Islamic State in Iraq and Levan (ISIL or ISIS).
White House officials were at the White House Saturday night in preparation.
An official told CNN that the message would be in the diplomatic reception room.