Basic editing is based on the powerful editing of CRISPR genes, but is more precise and multifunctional – it "directly writes new genetic information to a specific DNA site," according to the document.
In the traditional approach CRISPR-Cas9 Cas9, a type of modified protein, acts as a pair of scissors that can snap parts of strands of DNA. It can target genes at a specific location – for example, to disrupt a mutation.
About two-thirds of the known genetic variants of humans associated with the disease are genetic mutations at one point, so that genetic editing has the potential to correct or reproduce such mutations.
Industrial editing CRIS9 editing CRIS9 , which can generate new DNA. The tool cuts the strand of DNA and then transfers the edited sequence to the target DNA – allowing researchers to seamlessly insert and delete parts of human cells.
The technique allows researchers to search for and replace entire stretches of DNA strands, all without destructive breaks or donor DNA. With this method, researchers say they hope to correct up to 89% of the known genetic variants causing the disease accurately and efficiently.
"The versatility of original editing is quickly becoming apparent as we develop this technology," says Andrew Anzalone, another author of the study, in a statement on the press. "The fact that we could directly copy new genetic information to a target site was a revelation. We were really excited."
The team of researchers will continue to work to refine the technique, trying to maximize its effectiveness in different cell types. and investigation of possible effects on cells. They will also continue to test different disease models to ultimately "provide a potential avenue for therapeutic applications in humans," according to a press release.
Institute, and elsewhere, we hope CRISPR will one day target a wide range of "bad" genes – potentially helping people avoid obesity, Alzheimer's disease, genetic forms of deafness, and more.
Shortly earlier this year, in March, a group of researchers, including a scientist, who created and patented CRISPR technology called for a global moratorium on human germline editing – changes made to inherited DNA that could be transmitted to the next generation.