Homehttps://server7.kproxy.com/servlet/redirect.srv/sruj/smyrwpoii/p2/Sciencehttps://server7.kproxy.com/servlet/redirect.srv/sruj/smyrwpoii/p2/People can restore the limbs while scientists reveal a "DNA switch"
People can restore the limbs while scientists reveal a "DNA switch"
People of the Future Could FACE Limbs! A "DNA switch" that controls the regeneration genes used by worms to grow their bodies once it has been cut in half
Scientists have found that non-coding or "junk" controls the regeneration of DNA
jellyfish, marine anemones and mountainworms
Junk DNA controls activation of a gene called early growth response (EGR)
People have EGR to restore cells but do not cause regeneration on a large scale
Researchers now try to change the gene so that we can and "Regenerate"
From Victoria Bell to Mailonline
Published: 08:47 EDT, March 1
5, 2019 | Human beings could one day have the ability to grow back their body parts after a "DNA switch" that can activate the genes that control regeneration. Updated: 10:07 EDT, March 15, 2019
Animals such as salamanders and geckons can reject parts of their bodies to escape predators and grow new ones that have been cut off for only a few months.
Planetary worms and jellyfish go one step further by regenerating their whole body after
Now a team of scientists have studied the genes of three-band panther worms to shed light on how they do that.
They found that a "master" control gene called Early Growth Response (EGR)
They traced a DNA switch that could give people the ability to grow back your limbs. Animals such as salamanders or geckons can reject parts of their bodies to escape predators and form new parts. The study explores genetic switches in three-band panther worms ” class=”blkBorder img-share” />
Scientists have discovered a DNA switch that can give people the ability to grow back their limbs. Animals such as salamanders or geckons can reject parts of their bodies to escape predators and form new parts. The research explores genetic switches in three-band panther worms
Researchers at Harvard University have discovered that a portion of non-coding DNA, controversially marked by someone as "junk" DNA, controls activation of EGR acting as a power switch
Non- DNA regions are not directly involved in the process of creating proteins that trigger a whole range of biological processes.
This has led some to believe that these sections of our genes and those of other animals do not serve any useful purpose.
More recent research shows that the picture is much more complicated, including the Harvard study.
People now have an EGR key that repairs the cells but does not seem to cause regeneration on a large scale.
Scientists believe that the gene is connected differently to humans and is now trying to find a way to change it to reap so that we can also "regenerate." "What we have found is that this chief gene is coming … and that's the activation of genes that are involved during regeneration," said Dr. Andrew Gerke, a Harvard PhD student and lead author of the study.
"In general, what happens is that non-coding regions tell the coding regions to turn on or off, so a good way to think about it is that they are switches."
Animals such as salamanders or gecko can reject parts of their bodies to escape predators and form new parts for only a few months. Planetary worms and jellyfish, here, can go one step further by regenerating their whole body after being cut in half
WHAT CAUSES THE TYPES to regenerate?
All organisms, including humans, have the ability to regenerate to an extent, but the process is much more advanced in many invertebrates, such as earthworms and sea stars.
These animals can grow new heads, tails and other body parts when injured.
Scientists do not know why mammals do not have the same ability but regenerate skin, muscles and blood. Each multicellular organism is made up of a cell that divides into two identical cells, then four, and so on.
Each of these cells contains exactly the same twisted DNA strands and is considered pluripotent – meaning it can lead to all possible cell types in the body. But somewhere along the way, these starter cells, known as embryonic stem cells, are resigned to a different fate and become cells of the skin, heart cells, muscle cells, or other cell type.
For this process of DNA work in worm cells, which is usually tightly folded and thickened, it needs to be changed by creating new activation zones.
Parts of these very tightly packed parts of the genome – the complete genetic code of the investigated worms – physically become more open, experts say.
They act as regulatory switches to reverse the genes are dynamic and rapidly changing as the different parts are opened and closed.
While the study reveals new information about how the process works on worms, it can also help explain why this is not the case. Work with people. Dr. Mansy Srivastava, assistant professor of organisms and evolutionary biology, who led the study, said: "The question is: If people can include EGR and not just include it, but do it when our cells are hurt, why can not we refresh?
"The answer may be that if the EGR is the key to the power supply, we think the wiring is different
" What recycles EGR in human cells may be different from what is spoken
"We want to understand what these connections are and then apply this to other animals, including vertebrates, which can only make more limited regeneration."
The complete research findings were published in Science.