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Remdesivir: Do not use the drug that Trump takes for Covid-19, says WHO | World news

Remdezivir, one of the drugs that Donald Trump took when he developed Covid-19, should not be used in hospitals because there is no evidence that it works, advises the World Health Organization.

The American president was an enthusiastic supporter of the drug to the point where in July he boasted that he had bought the entire stock of the world for Americans. However, the WHO Guidelines Committee said that patients with Covid could be better off without it.

The WHO has issued what he calls “living guidelines”

;, which can be updated with the receipt of evidence, largely as a result of the Solidarity process, which he is leading in several countries. Solidarity randomly divided patients into several medicines, including remdezivir, and found that those who took it were no more likely to experience severe Covid than those who did not.

There are other problems with remdezivir. Manufactured by the American company Gilead, it is extremely expensive and must be given intravenously. The guidelines, published in the British Medical Journal, conclude that “most patients would not prefer intravenous treatment with remdezivir given the low safety. Any beneficial effects of remdezivir, if any, are likely to be small and the possibility of significant harm remains. “

Earlier this year, there were high hopes for the antiviral drug, one of the few drugs that the U.S. Food and Drug Administration has given an emergency authorization for use against Covid-19. Some other countries also recommend its use.

Peter Horby, a professor of emerging infectious diseases and global health at Oxford University’s Nafield Medical Department, who is conducting a study to restore treatment with Covid, said the way remdezivir is used in the pandemic needs to be rethought.

Solidarity, which analyzed the results of more than 7,000 adults admitted to a Covid-19 hospital in four randomized controlled trials, found no evidence of significant benefit, he said.

“Given this lack of evidence of any benefit to mortality, risk of ventilation or time to clinical improvement, the World Health Organization has reasonably recommended that remdezivir not be used in patients hospitalized with Covid-19, regardless of their disease severity.

“Remdezivir is an expensive drug that must be given intravenously over five to ten days, so this recommendation will save money and other health resources. Remdezivir is recommended in several directions for treatment with Covid-19, so this new analysis will require a rethinking of the place of remdezivir in Covid-19. “

Older and cheaper drugs have shown real benefits. The steroid dexamethasone has been shown to save every eighth life among people seriously ill in a hospital with Covid.

Trump also took dexamethasone, although he was not in the seriously ill category, and experiments show that it has a small effect obtained earlier in the disease. He also took an antibody cocktail from the company Regeneron, which is not usually available, although scientists believe there is promise.

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