The secret to living in the last 100 may lie in your immune system, new research suggests.
In a study recently published in the Proceedings of the National Academy of Sciences (PNAS), scientists find that supercenters – those 110 years of age or older – have an overblown of a particular type of cell fighting immune diseases their system, probably explaining their longevity.
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in "circulating immune cells" from supercenters and controls aged 50 to 89. About 41,208 immune cell samples are taken from seven supercenters, 99 cells3 were collected from the five controls. as approximately the same amount of T cells as a whole, the former group has an excess amount of one particular subset of T cells called cytotoxic CD4 T cells. These reports, according to the results release message, are aggressive and quickly destroy the cancer and infectious cells.
In some cases, cytotoxic CD4 T cells represent 80 percent of the supercenters T cells, while only 10 to 20 percent of the control T cells are cytotoxic CD4 T cells, according to a study conducted by the Center for Integrative medical sciences RIKEN (IMS) and Keyo University School of Medicine in Japan.
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Cells of the "super" immune system are probably not a marker of youth, but rather a "special feature of supercenters", the researchers write. Cytotoxic CD4 T cells are probably the offspring of a single "ancestral cell".
"We believe that these types of cells, which are relatively wicked in most individuals, even young ones, are useful in fighting established tumors, and may be important for immuno-surveillance," RIKEN Piero Deputy Director said in a statement. Carninci. "This is exciting because it gives us a new idea of how people who live very long lives are able to defend themselves against conditions such as infections and cancer."