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Task Force Updates Breast Cancer Recommendations



TUESDAY, Aug. 20, 2019 (HealthDay News) – Mutations in two genes – BRCA1 and BRCA2 – are known to significantly increase the risk of breast cancer, but experts have long debated which women should be tested for them.

New recommendations from the U.S.A. The Preventive Services Task Force (USPSTF) may help clarify who can benefit from a risk assessment test. Now, if a woman is at high risk, the task force is recommending that she see a genetic counselor and possibly be tested for BRCA mutations.

"Breast cancer is very prevalent, but BRCA founder mutations are rare, occurring in less than 1

% of all women," explained task force member Dr.

. Carol Mangione is a professor of medicine and public health at the University of California, Los Angeles.

Deciding whether to have a test for these mutations is "a complex decision with a lot of pros and cons to weigh," she said. "Women who are known to be positive sign ups for some pretty dramatic surgeries and medications."

For example, women with a BRCA mutation may have both breasts removed to prevent cancer from developing.

"In women who do not have an increased risk [of a BRCA mutation]the potential harms outweigh the benefits of testing," Mangione said.

The latest USPSTF recommendations for BRCA testing were published Aug. 20 in Journal of the American Medical Association .

So who should have that initial risk assessment?

According to the task force, it is appropriate for women with a personal or family history of these cancers. :

  • Breast
  • Ovarian
  • Fallopian tube
  • Peritoneal (the tissue lining the abdomen).

Women with an ancestry linked to BRCA mutations, such as those of Ashkenazi Jewish descent, should also have a risk assessment, the task force said.

Other groups that may have an increased risk of BRCA mutation due to ancestry include some African-Americans, Mexicans, Nigerians, and people from India, according to an editorial published Aug. 20 and JAMA Network Open . Its lead author is Dr. Padma Sheila Rajagopal of the University of Chicago.

Depending on the results of a risk assessment, a woman may not end up having genetic counseling or testing. It's also possible that a woman may have genetic counseling and then decide BRCA testing would not benefit her.


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