Scientists believe that it may be possible to reverse a person's biological age with a combination of drugs and growth hormones based on the evidence presented in the results of a small clinical trial.
The study, conducted by geneticist Steve Horvath at the University of California, Los Angeles, effectively turned the participants' epigenetic clock an average of two and a half years, according to the journal Science Nature . In addition, patients' immune systems appear to be rejuvenated after treatment with the combination of growth hormone and two diabetes medicines.
Even the scientists who worked on the study were surprised by the results. At the same time, some insist on caution as the results are still preliminary.
"I expected to watch the clock slow, but not the twist," Horvath tells Nature . "It was kind of futuristic."
Wolfgang Wagner, a cell biologist at the University of Aachen in Germany, said the study was very small, making it difficult to draw firm conclusions.
"It may have an effect," Wagner said. "But the results are not hard because the study is very small and not well controlled."
Published in Aging Cell in the past week, the initial study tested generic cocktails of nine men between the ages of 51 and 65, all of whom were white. Initially, the primary purpose of the study was to monitor the efficacy and safety of the use of growth hormone for tissue repair in the thymus gland. between the chest, lungs and chest, the gland is vital for effective functioning
Immunologist Gregory Fahy, chief scientific officer and co-founder of Intervene Immune in Los Angeles, led this initial study, which began as early as 2015. Later he asked Horvath to analyze the results to determine the effect on the patient's epigenetic clock or biological age.
Horvath explained that the results showed that "the biological effect of treatment is stable."
"Because we can track changes within each individual and because the effect was so strong in each of them, I am optimistic," "
During the treatment period, researchers took regular blood samples from participants. Constant tests revealed that each patient rejuvenated the number of blood cells during and after the study. In seven of the nine patients, the study also found that the fat accumulated n was replaced by regenerated thymus tissue.When the study was completed and these results were presented, Horvath analyzed the biological markers of the patients, determining that standard aging indicators were not simply delayed but reversed.a combination of drugs and their effects on But according to Sam Palmer, a cancer oncology immunologist at the University of Heriot-Watts in Edinburgh, the study has "huge implications."
Metformin, a diabetes drug used in the process, is already being tested by scientists to determine it Otto impact diseases associated with aging. The combination of drugs will now need to be further explored.