Tear gas was released to disperse protesters in Egypt in some of the first protests since President Abdul Fatah al-Sisi took power in 2014.
Hundreds of Egyptians filled Tahrir Square in Cairo ̵
Demonstrations were held elsewhere in the country.
The protests were in response to allegations of corruption against President Sisi's government.
- Paying the price of seeking freedom in Egypt
- Country profile in Egypt
Five people have been arrested on vacation, AFP reported.  An Egyptian businessman and actor, Mohammed Ali, posts online videos accusing the country's leader of losing millions to luxury residences and hotels while millions of Egyptians live in poverty. Egypt has been pursuing a policy of economic austerity in recent years.
President Sissy dismissed the allegations as "lies and slander."
What happened on Friday?
"Sisi out" and "People want to take down the regime" topped Egypt's Twitter trend on Friday.
Hundreds of anti-regime protesters gathered in and around Tahrir Square, despite efforts to disperse them.
Demonstrations were also reported in the second largest city in Egypt, Alexandria, as well as in Suez and the city of Mahala el-Kubra, which is north of Cairo.
Even a few days ago, such scenes would be "unthinkable," BBC correspondent Sally Nabil tweeted .
Mr Ali, who lives in self-imposed exile in Spain, published his first video on 2 September. In a video posted Tuesday, he reports that if President Sisi does not resign by Thursday, "the Egyptian people will go to the squares on Friday to protest."
In 2013, Mr. Sisi led the military overthrow of Egypt's first democratically elected president, Mohamed Morsey, following protests against his rule.
Since then, he has controlled what human rights groups say is unprecedented opposition to dissent that has led to the arrest of tens of thousands of people.
The Egyptians voted to approve the constitutional changes in April, which could extend Mr Sisi's term to 2030, with a turnout of 44%.
He won 97% of the vote in the 2018 presidential election, when there was no serious opposition.