A small clinical trial in California for the first time suggests that it is possible to reverse the body's epigenetic clock, which measures a person's biological age.
In one year, nine healthy volunteers took a cocktail of three common drugs – growth hormone and two diabetes drugs [metformin and DHEA] – and averaged 2.5 years of their biological age, as measured by scans on the human genome . Participants' immune systems also showed signs of rejuvenation.
The results were surprising even for test organizers – but researchers warn that the findings are preliminary because the test is small and does not include a control frame.
"I expected to watch the clock slow, but not the twist," says geneticist Steve Horvath.
Researchers are already testing metformin for its potential to protect against common age-related diseases such as cancer and heart disease. [Researcher Gregory] Fahi says the three drugs in the cocktail can contribute separately to the effect on biological aging through unique mechanisms, and Intervene Immune is planning a larger study involving people of different ages and ethnicities and women.
Read the full, original pub ikatsiya: The first hint that the biological age of the organism may be changed