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The microbiome may participate in mechanisms related to muscle strength in the elderly



  The microbiome may be involved in mechanisms related to muscle strength in adult adults
A new study identifies differences in the composition of the gut microbiome in physically highly functioning versus low-functioning adult adults, successfully transferring some of these effects to mice. Credit: Pixabay

A new new study suggests that the gut microbiome plays a role in the mechanisms associated with muscle strength in adult adults. The work, led by researchers at the Jean Mayer USDA Human Nutrition Nutrition Research Center (HNRCA) at Tufts, is available as preliminary proof before printing in Experimental Gerontology .

The intestinal muscle axis, or the relationship between the gut microbiota and muscle mass and physical function, has been gaining ground as a research topic in the last few years, as studies have found that the gut microbiota affects many aspects of health. While researchers have begun exploring the relationship between gut microbiome, muscle, and physical function in mice and young adults, several studies have been conducted with older adults.

To get an idea of ​​this population, researchers compared gut bacteria from 1

8 adult adults with high physical function and favorable body composition (higher percentage of lean mass, lower percentage of fat) with 11 adults adults with low physical function and less favorable body composition. The small study found differences in bacterial profiles between the two groups.

Similar bacterial differences are present when mice were colonized with faecal samples from both human groups and adhesion strength increased in mice colonized with samples from high-functioning adult adults, suggesting a role for the gut microbiome in mechanisms, related to muscle strength in older adults.

Specifically, compared to the low-functioning adult age group, the researchers found higher levels of Prevotellaceae, Prevotella, Barnesiella and Barnesiella intestinihominis – all potentially good bacteria – in high-functioning adult adults and mice that were colonized with faecal samples from high-functioning adult adults.

No significant differences in body composition or durability of colonized mice were observed; However, the researchers note that the length of the intervention period was short and these data may warrant further study.

"Although we were surprised to find no role for the gut microbiome in maintaining body composition, these results are now beginning to understand the role of gut bacteria in maintaining muscle strength in adults," says Michael Lustgarten, last and relevant study author and researcher at the Nutrition, Exercise Physiology and Sarcopenia (NEPS) Laboratory at the HNRCA. "For example, if we were conducting an intervention to increase Prevotella levels in the gut microbiome, we would expect to observe is to increase muscle strength if these bacteria are involved. The role of Prevotella in maintaining muscle strength in older adults is one area we look forward to exploring. "

" With advancing age, body composition, muscle strength and lean mass are decreasing, "says first author Roger Fielding, director of the NEPS lab at HNRCA." Identifying the differences in bacteria present in high-functioning and low-functioning groups in this study, it directs us to a more complete understanding of both the gut microbiome and healthy aging. "

For the study, researchers measure lower limb function, mobility and strength in the sedentary adult adult group. (age 70-85 years) in the first and one-month studies In mice, they measured body composition with magnetic resonance imaging and grip strength and endurance of the treadmill to test physical function. Fecal samples from the elderly were transplanted into Four weeks after faecal transfer, researchers measured the body composition, physical function and gut microbiome of 18 mice colonized with faecal samples from a high-functioning human group and 18 mice, col. Hezir with fecal samples from human niskofunktsionalnata group. [19659005] The authors note the small sample size and short time frame as potential limitations of the study.


Study shows that gut microbiota affect skeletal muscle mass and function in mice


More information:
Roger A. Fielding et al. Muscle strength is increased in mice colonized with microbiota from high-functioning adult adults, Experimental Gerontology (2019). Doi: 10.1016 / j.exger.2019.110722

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Tufts University

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The microbiome may participate in mechanisms related to muscle strength in adults (2019, September 18)
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