Urolithin A, a metabolite of biomolecules found in pomegranates and other fruits, can help slow down some aging processes. The EPFL spin-off Amazentis, together with EPFL and the Swiss Institute of Bioinformatics, published an article in the journal Nature Nature Metabolism describing the results of their clinical trial.
The fact of life is that skeletal muscles begin to lose strength and mass when a person reaches 50 years of age. A recent clinical trial involving two EPFL substances ̵
The Delay of Mitochondrial Aging
The claim that healthy eating is the key to a longer life may seem too convenient, but it is now supported by scientific evidence. The pomegranate, a fruit that many civilizations value for the health benefits, contains ellagitannins. When swallowed, these molecules turn into a compound called urolithin A (UA) in the human gut. Researchers have found that UA may delay the aging process of mitochondria. The catch is that not everyone produces a natural UA
To overcome this problem and make sure all participants received the same dose, the team synthesizes the compound. About 60 elderly people, all of whom were healthy, took a single dose between 250 and 2000 mg UA. Researchers noticed side effects compared to the control group receiving placebo. Subjects were then divided into four groups, each receiving placebo, or 250, 500 or 1000 mg daily UA dose for 28 days. Again no adverse effects on health were detected, even after prolonged ingestion. The team then evaluates the efficacy of UA by examining cellular and mitochondrial biomarkers in the blood and muscle tissue of the participants. The results are convincing: UA stimulates mitochondrial biogenesis – the process by which cells increase mitochondrial mass – in the same way as regular exercise.
UA is the only known compound that restores the ability of cells to recycle defective mitochondria. In young people this process happens naturally. But when we get older, our body begins to lose its power to clean dysfunctional mitochondria, causing sarcopenia (loss of skeletal muscle mass) and weakening other tissues. The team focuses on the delay or even reverse movement of this natural aging effect.
The document published today also confirms that the compound is safe to eat. Amazentis, based in EPFL's innovation park, hopes to use promising results to bring the product to the market quickly. "These recent findings, based on previous preclinical studies, really crystallize how UA can become a game of change in human health," said Johann Auverks, a professor at LISP, the EPFL laboratory involved in the study. An article published in 2016 showed that the life of nematode worms exposed to UA increased by 45% – from about 20 to 30 days – compared to the control group. Likewise, older mice show 40% better endurance while running after two weeks of treatment. Thus, the compound may have even more secrets to reveal the benefits to human health.
The pomegranate finally reveals its powerful anti-aging secret
Pénélope A. Andreux et al. The activating mythophagus urolithin A is safe and induces a molecular signature of improved mitochondrial and cell health in humans Nature Metabolism (2019). DOI: 10.1038 / s42255-019-0073-4
The combination of pomegranate with anti-aging effects goes through human experience (2019, June 17)
restored on June 17, 2019
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