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The quantum thermometer using nanodiamonds detects “fever” in small worms C. elegans

Take diamonds, measure the temperature

C. elegans temperature measured by tracking embedded nanodiamonds. Credit: Masazumi Fujiwara, Osaka City University

A team from Osaka City University, in collaboration with other international partners, demonstrated a reliable, accurate, microscope-based thermometer using quantum technology that measures the temperature of microscopic animals. The technology detects temperature-dependent properties of quantum spins in fluorescent nanodiamonds.

The study was published in Scientific progress.

The optical microscope is one of the most basic analysis tools in biology, using visible light to directly observe microscopic structures. In the modern laboratory, fluorescence microscopy, an improved version of optical microscopy using fluorescent biomarkers, is now more widespread. Recent advances in fluorescence microscopy have allowed vivid imaging of the details of a structure and thus obtaining various physiological parameters in those structures, such as pH, reactive oxygen and temperature.

Quantum detection is a technology that uses the ultimate sensitivity of fragile quantum systems to the environment. High contrast MRIs are examples of quantum rotations in fluorescent diamonds and are one of the most advanced quantum systems operating in the forefront of real-world applications. Applications of this technique in thermal biology were introduced seven years ago to quantify temperatures in cultured cells. However, they have not yet been applied to dynamic biological systems, where heat and temperature are more actively involved in biological processes.

The research team decorated the surface of nanodiamonds with polymer structures and injected them into the nematode worms C. elegans, one of the most popular animal models in biology. Researchers are trying to learn the basic healthy temperature of worms. Once inside, the nanodiamonds moved quickly, but the team̵

7;s new quantum thermometry algorithm successfully tracked them and constantly measured the temperature. Researchers cause fever in worms by stimulating their mitochondria with pharmacological treatment. The team’s quantum thermometer successfully monitors an increase in worm temperature.

“It was fascinating to see how quantum technology works so well in live animals, and I never imagined that the temperature of small worms smaller than 1 mm could deviate from the norm and turn into a fever,” Masazumi said. Fujiwara, a professor in the Department of Science at Osaka City University. “Our results are an important step that will steer the future direction of quantum perception, as it shows how it contributes to biology,”

The first quantum orientation by improving the measurements of quantum entanglement

More info:
“Real-time nanodiamond thermometry examining in vivo thermogenic reactions” Scientific progress (2020). DOI: 10.1126 / sciadv.aba9636

Provided by Osaka City University

Quote: Take diamonds, measure temperature: The quantum thermometer using nanodiamonds feels “fever” in small worms C. elegans (2020, September 11), extracted on September 12, 2020 from https://phys.org/news/2020-09- diamonds-temperature -quantum thermometer-nanodiamonds.html

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