A group of volunteers who have made a journey in the name of science have helped the researchers find out how LSD is confused with brain activity to induce altered state of consciousness.
Brain scanning of individuals with high drug content indicates that a chemical allows parts of the bark to be flooded with signals that are usually filtered to prevent information overload.
The drug allows more information to flow from the thalamus, a kind of nervous janitor, to an area called the back of the dental cortex, and derives from the flow of information to another part known as the temporal cortex
. be the basis of some of the umbrella effects reported by LSD users, the feeling of bliss and the fact that they are in line with the universe to hallucinations, and what scientists in the field call the "ego disintegration," where the feelings of myself.
For the study, the researchers invited 25 healthy subjects to be scanned under the influence of LSD and in another case after taking placebo. They were pre-screened around the scanner to make sure they feel comfortable coming inside when the drug stays up. If the machine suddenly turns into a threatening behavior, scanning may not have gone so well. It says that LSD causes the thalamus to stop filtering the information it is relaying to other parts of the brain. This is the destruction of this filter, which produces strange effects that the drug causes, or so the thought goes.
"The world around us is not the world we perceive because the thalamus filters what it considers to be inappropriate information. "Said Catherine Preler, project researcher at the Zurich University Psychiatric Hospital. "We do not necessarily take everything because it would be overloading information."
Scanning the brains of volunteers suggests there may be some truth in the hypothesis. The LSD thalamus provides more information to some parts of the brain and suppresses information related to others. "What we've found is that the model is mostly true, but how information is distributed in the bark at LSD is much more specific than expected," said Preller.
It is unclear how confused the flow of information in the brain gives rise to certain LSD-related sensations, but there are some hints from previous work. It is believed that, for example, the back of the dental cortex plays a role in shaping one's own feeling, so overloading can cause self-indulgence. LSD or lysergic acid diethylamide was the first one to be synthesized in 1938 and had a profound impact on psychology and psychiatric research in the 1950s and 1960s. Although accepting it as a recreational medicine has led to its ban, many scientists now suspect that it may be a powerful weapon in the fight against depression and other mental disorders. "We are getting closer to understanding the complexity of what's happening with LSD in the brain, and that's especially important if we want to develop new drugs," said Preleur. The most recent study is published in a collection of reports from the National Academy of Sciences.
The work follows a major study in 2016, which found that, under the influence of LSD, the brain is gaining more visual processing regions than ordinary people, enriching people's images. I saw even when their eyes were closed. The study is the first to show how the LSD brain looks like a modern scanner.