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Home https://server7.kproxy.com/servlet/redirect.srv/sruj/smyrwpoii/p2/ Health https://server7.kproxy.com/servlet/redirect.srv/sruj/smyrwpoii/p2/ The use of right-sided disease plays a key role in the development of Alzheimer's disease, scientists say

The use of right-sided disease plays a key role in the development of Alzheimer's disease, scientists say



Common gum disease plays a "central role" in the development of Alzheimer's disease, scientists say.

The new evidence that infectious bacteria are progressing Alzheimer's disease can potentially turn the current thinking about how to overcome the disease. Porphyromonas gingivalis is one of the main causes of gum disease and tooth loss in humans and is associated with arterial damage.

There have been previous suggestions that it may play a role in Alzheimer's disease, but the latest study by a US-led international team of scientists seems to pose the question no doubt

The researchers made the discovery after analyzing brain tissue, spinal fluid and saliva from dead and living patients diagnosed with and suspected of Alzheimer's disease.

The gene was also found in the spinal cord fluid of seven of 10 living patients diagnosed with Alzheimer's disease

Samples from saliva of 10 patients with suspected Alzheimer's disease turned out to be positive for the gene of P. gingivalis, the hippocampus, a part of the brain that is vital for memory, from P. gingivalis infection

It also reduces the inflammation and levels of beta-amyloid, a cerebral molecule strongly associated with Alzheimer's disease

Writing in the journal, the researchers conclude: "The results of this study show that P. gingivalis and gingipains in the brain play a central role in the pathogenesis of AD (Alzheimer's disease),

Bacteria can gain access to the brain by infect the cells of the immune system or spread through the cranial nerves, passes and in the head and jaw, the researchers say.

Laboratory tests have shown that gingivaline enzymes can trigger tau. entangled – protein nodes in the neurons that are thought to cause damage caused by Alzheimer's disease.

The study also supported a controversial idea that the beta-amyloid peptide is actually part of the brain's antimicrobial defense system. team.

P. Gingivalis infection is believed to nurture high levels of beta-amyloid that eventually became toxic

Traditional broad spectrum antibiotics are likely to be ineffective against P. gingivalis in the brain, according to the study. In laboratory experiments, antibiotics do not prevent cell death caused by P. gingivalis.

The bull is also shown rapidly to develop resistance against the broad spectrum antibiotic moxifloxacin, but not to COR388.

Dr. David Reynolds, chief scientific officer at the Alzheimer's Research UK research organization, said Alzheimer's disease may have several causes, one of which may be a gum disease from the gums.

He added: "Maintaining good dental health is an important part of a healthy lifestyle and while we still do not know to what extent it can affect the risk of dementia, the presence of a type of bacteria is extremely unlikely to be the only reason for this condition. "

Болест на десен засяга приблизително 45% от населението на Обединеното кралство, според Британската дентална асоциация (BDA).

Много видове бактерии допринасят за заболяването на венците, но P. gingivalis е един от най-важните.

Научният съветник на БДА професор Деймиън Уолмсли каза: "Това проучване предлага приветстващо напомняне, че здравето на устната кухина не може да остане допълнителна опция в нашата здравна служба.

" Всеки живот може да се подобри чрез редовни срещи и добра устна хигиена, намаляване на бактериалното натоварване, което някога е налице в устата ни до ниво, което е малко вероятно да причини кариес, заболяване на венците или загуба на зъб. "

Д-р Джеймс Пикет, ръководител на изследването в Алцхаймер общество, каза:" Лабораторната работа предполага, че тази инфекция може да причини увреждане на клетките на мозъка, но все още няма ясни доказателства, че тя може да причини тези увреждания при хора или да доведе до болестта на Алцхаймер. “Успехът на това ново лекарство зависи от това дали инфекцията наистина играе важна роля за болестта на Алцхаймер.

"Важно е да се преследва това, тъй като не е имало ново лекарство за деменция след 15 години. Предстоящото клинично изпитване ще бъде решаващ тест, за да се види дали това може да бъде потенциално лечение за болестта на Алцхаймер.

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