People who are naturally thin may be able to lose weight effortlessly because their fat cells are genetically more efficient, a study shows.
Scientists look at the action of fat cells in a group of men and women who,
The fat cells in their stomachs are nearly half full and have more energy to break down fats than those in middle-weight people.
The results add to the belief that thin people have some genetic advantages when it comes to maintaining their figure.
Thin people can keep their weight low because they have smaller fat cells with more energy, according to the ording of Swiss scientists (stock image)
Writing in the American Journal of Clinical Nutrition, researchers from Switzerland h said they thought their findings were first in the world.
They said, "We show for the first time, as far as we know, that persistent low body weight in humans is associated with features in white adipose tissue that are opposite to those of obese patients. "
The team looked at white adipose tissue, which is the main form of body fat. They store lipids, which are fatty substances in our diet.
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This suggests poor diet and lack of exercise – poor lifestyle choices – are mostly to blame, researchers said.
Scientists based in Norway examined the findings, including BMI measurements, from a previous study of 118,959 adults who had repeated height and weight measurements recorded between 1963 and 2008.
Participants were divided into five groups. depending on their genetic risk for obesity, one fifth is the most susceptible and the fifth least.
People in the upper genetic susceptibility group are more likely to have a higher BMI than those identified as at lower risk, found.
But the findings also show that BMI has increased for both genetically predisposed and predisposed humans since the 1960s.
The lead author, Maria Brandquist, PhD student, states: "Genetically predisposed people are at greater risk for higher BMI and that genetic predisposition interacts with the decontaminated environment, leading to a higher BMI.
'A changed food model is the most plausible environmental factor affecting excess energy balance.
"However, a more sedentary lifestyle and possible changes in the biological environment, such as toxins and the microbiota, can also contribute. "
The team at the Nestlé Institute of Health Sciences examines 30 men and women who remain very thin.
They have BMIs of 18.5 or lower, which would be considered premature by the NHS.
The authors note that these people did not have impaired eating patterns and ate and exercised a normal amount.
Participants had a small amount of fat cut from their stomach to be analyzed and also gave blood, urine samples. and feces.
Researchers found that fat cells of thin people have unusually high exp essay of genes involved in both degradation and fat formation
More than 200 variations of the gene affect weight, such as fat distribution and metabolism.
Fat cells of thin people are 40 percent more
Fatty tissue with less but larger cells is described as "hypertrophic", while fatty tissue with much smaller cells is "hyperplastic"
hypertrophic condition is associated with insulin resistance, diabetes and cardiovascular disease Javan as heart disease.
The results also show that thin fat cells in humans have more active mitochondria, part of a cell that uses energy to help the cell break down and renew itself.
As mitochondria operate at a higher level, fat cells break down and repair molecules more efficiently.
The researchers called the process a "barren lipid cycle" and could explain why lean people are resistant to weight gain, the authors said.
Effectively their fat cells are genetically inclined to burn so much fat for energy that they break down and restore other fat cells that they are not
in thin people, writes Dr. Geldof and his colleagues.
The results could eventually create new avenues for the treatment of weight loss.
Millions of people around the world are at risk of heart disease, stroke, type 2 diabetes and cancer due to being overweight.
In the UK alone, one in four adults is obese.
It has been previously discovered that obese people have defective mitochondria in their fat cells, which means they also cannot burn fat.
This can also lead to metabolic conditions, say authors who include diabetes.
The faeces of the thin participants show no difference, but they have lower levels of creatine, a by-product of the body, in their urine.
This may also explain why they have less muscle mass because of the low levels of creatinine normally as a sign of o is the loss of muscle mass with advancing age.