The bridegroom, whose wedding was directed by a suicide bomber in the Afghan capital Kabul, says he "lost hope" after the deadly attack.
In a television interview, Mirwiss Elmie said his bride survived, but his brother and other relatives were among 63 people killed in Saturday's attack.
The Islamic State group has admitted that it carried out a bombing that injured more than 1
President Ashraf Ghani described the attack as "barbaric".
He blames the Taliban for "providing a platform for terrorists." Taliban involved in peace talks with US have condemned the attack.
- What can peace in Afghanistan look like?
In an interview with Tolo News, Mirwiss Elmi recalled welcoming smiling guests only to the crowded wedding hall.
"My family, my bride are shocked, they can't even talk. My bride continues to be afflicted," he said.
"I lost hope. I lost my brother, I lost my friends, I lost my loved ones. I will never see happiness in my life again.
" I cannot go to funerals, I feel very weak … I know that this will not be the last suffering for the Afghans, the suffering will continue, "he added.
The bride's father told Afghan media that 14 members of his family were killed in the attack.
An IS statement said that his fighters had exploded at a "grand assembly" while others "blew up a parked vehicle with explosives" when emergency services arrived.  The attack was carried out in an area populated mainly by Shiite Muslims.
Sunni Muslim fighters, including the Taliban and the Islamic State group, have repeatedly targeted the Shi'a Khazar minorities in Afghanistan and Pakistan.
Speaking from a hospital bed, wedding guest Munir Ahmad, 23, said his cousin was among the dead.
"The wedding guests were dancing and celebrating when the blast happened," he told AFP.
"There was complete chaos after the explosion. Everyone was screaming and crying for their loved ones."
Afghan weddings are often held in large halls where men are separated from women and children.
What was the reaction?
Writing on Twitter, President Ghani said he had convened a security meeting to "review and prevent such security gaps."
Afghanistan's Chief Executive Abdullah Abdullah described it as a "crime against humanity" and the American Afghanistan's ambassador, John Bass, called it "utter corruption".
A Taliban spokesman said the group strongly condemned the attack.
"There is no excuse for such deliberate and brutal killings and targeting of women and children," Zabiul ah Mujahideen said in a text message to the media.
How are the peace talks in Afghanistan going?
On Sunday, US President Donald Trump told reporters in New Jersey that negotiations were going well.
"We have very good discussions with the Taliban. We have a lot of discussions good discussions with the Afghan government ", k for it.
The United States has about 14,000 troops in Afghanistan and is part of the NATO mission there. Since his presidency, Mr. Trump has said he wants to pull US troops out.
The deal will involve a phased withdrawal of US troops in exchange for assurances from the Taliban that Afghanistan will not be used by extremist groups to attack US targets.
The Taliban will also begin negotiations with the Afghan delegation on a peace framework, including a possible ceasefire. The militants refuse to negotiate with the Afghan government until a timetable for US withdrawal is reached.
The Taliban is now in control of more territory than at any time since it was forced into power in 2001.